The Blizzard Entertainment Employment Opportunities Website now lists Art Director for Diablo III as an open position (thanks Kotaku), which causes recent controversy over the game's art direction (story) to come to mind. IncGamers has a follow-up statement from Blizzard indicating that this was not based on fan complaints about the art direction, and that the new art director will continue along the same path:

Regarding Brian, he recently resigned to form a startup technology company (outside the game industry), which is why we've posted about the open position. This change won't impact the game: we're really pleased with the look and feel that Brian helped create for Diablo III, and the new person we bring onboard will work with the other artists on the team to maintain the art style moving forward.