AMD support now offers new version 16.2.1 Crimson reference drivers for AMD graphics cards (thanks Mashiki). These include a crossfire profile for the newly released Far Cry Primal, and resolves a number of outstanding issues, though there are still a few titles that can crash when using their Gaming Evolved overlay. Here's word:

Radeon Software Crimson Edition 16.2.1 Highlights

• Crossfire Profile available for
  • Far Cry Primal

Resolved Issues

• A black screen/TDR error may be encountered when booting a system with Intel + AMD graphics and an HDMI monitor connected
• Choppy gameplay may be experienced when both AMD Freesync™ and AMD Crossfire™ are both enabled
• Display corruption may be observed after keeping system idle for some time
• Fallout 4 - Flickering may be experienced at various game locations with the v1.3 game update and with AMD Crossfire™ enabled
• Fallout 4 - Foliage/water may ripple/stutter when game is launched in High/Ultra settings mode
• Fallout 4 - Screen tearing in systems with both AMD Freesync™ and AMD Crossfire™ enabled if game is left idle for a short period of time
• Fallout 4 - Thumbnails may flicker or disappear while scrolling the Perk levels page

• Far Cry 4 - Stuttering may be observed when launching the game with AMD Freesync™ and AMD Crossfire™ enabled
• FRTC options are displayed on some unsupported laptop configurations with Intel CPU's and AMD GPU's
• Radeon Settings may sometimes fails to launch with a "Context Creation Error" message
• Rise of the Tomb Raider™ - Corruption can be observed at some locations during gameplay
• Rise of the Tomb Raider™ - Flickering may be experienced at various game locations when the game is left idle in AMD Crossfire™ mode under Windows 7
• Rise of the Tomb Raider™ - Game may intermittently crash or hang when launched with very high settings and AA is set to SMAA at 4K resolution
• Rise of the Tomb Raider™ - Lara Croft's hair may flicker in some locations if the Esc key is pressed
• Rise of Tomb Raider™ - A TDR error may be observed with some AMD Radeon 300 Series products after launching the "Geothermal Valley" mission
• The AMD Overdrive™ memory clock slider does not show original clock values if memory speeds are overclocked
• World of Warcraft runs extremely slowly in quad crossfire at high resolutions
• Known Issues
• A few game titles may fail to launch or crash if the Gaming Evolved overlay is enabled. A temporary workaround is to disable the AMD Gaming Evolved "In Game Overlay"
• Star Wars™: Battlefront - Corrupted ground textures may be observed in the Survival of Hoth mission
• Cannot enable AMD Crossfire with some dual GPU AMD Radeon HD 59xx and HD 79xx series products
• Fallout 4 - In game stutter may be experienced if the game is launched with AMD Crossfire enabled
• XCOM 2 - Flickering textures may be experienced at various game locations
• Rise of the Tomb Raider™ - The game may randomly crash on launch if Tessellation is enabled
• Core clocks may not maintain sustained clock speeds resulting in choppy performance and or screen corruption