Blizzard took to the Battle.net forums to outline some changes to how two-handed weapons work in Diablo III. Two-handers have been junk since the release of the action/RPG sequel, and they are springing to action to address this:

To summarize the changes:

• The DPS of 2-Handed Melee Weapons has been increased by 23-26% across the board.
• This applies to the following weapon types:
  • 2-Handed Maces
  • 2-Handed Mighty Weapons
  • 2-Handed Axes
  • 2-Handed Flails
  • 2-Handed Staffs
  • 2-Handed Swords
  • Daibos
  • Polearms
• In direct response, Heavenly Strength will now reduce damage done by 20%. With both changes, Crusaders using a 2-Hander should see a very small DPS increase.
• This change is retroactive to existing live items.
• This change only affects level 70 two-handed melee weapons.
• This change affects two-handed melee weapons of all rarities.

We are still considering additional changes if needed but this should be a solid step towards making 2-Handers viable again for all classes.