There's an Interview with Obsidian on CVG talking with Feargus Urquhart about "life after South Park" that discusses a range of topics, including whether they are still an RPG studio, plans for more AAA development, IPs they would enjoy working with, and more. As noted on Joystiq (thanks nin), Feargus also gives a sense for when they might try their next Kickstarter campaign:

We are working on what that is. I think we've come up with what it's going to be. We have to still firm up some details, but my hope is that we'll get one going before the end of the year.

I think we've got a good idea. I'm not going to share anything, but a few times in my career I have these things where I say, "hey, that's a cool idea!" and I've generally been right. So I think this one's going to be a cool thing.