The Paul Neurath Interview on Grupo 97 talks with the founder of Blue Sky Productions (which became Looking Glass Studios) as well as Floodgate Entertainment, composed of many former Looking Glass employees. Topics include fan reverence for Looking Glass, his fondest memory of the Looking Glass days, the variety of genres he's explored, development challenges, dealing with writer's block, dealing with publishers and distributors, the current state of game development, dealing with the press, and lots about game development philosophy. Here's his outlook on PC gaming:

Yes, the broad notion that PC games are less profitable than console games is not accurate. Some PC games are among the most profitable games in recent years, and continue to sell in huge numbers. Many, perhaps the majority, of console games today are break-even or lose money. That being said, top selling XBOX, WII or Playstation games do typically outsell the top selling single-player PC games, and in terms of gross revenues, if you exclude MMO’s, I believe that console games outsell PC by a wide margin.

I think it would be hard to justify the economics of a modern single player focused PC game such as Thief or Ultima Underworld, which is why so few are produced. But if you could pull off this same game genre with aplomb on an XBOX or Playstation, you could do just fine.