I'm actually sorta encouraged by the 'Fall 2008' release date. That means they'll have had nearly two years working full steam with all of BethSoft's resources (and more with a smaller team before that. It'll all be running on an engine that's already had over a year of public release to get bugs worked out. If they can't pull out something that puts Oblivion to shame given the depth and variety present in the Fallouts and all the time they've had to work on it...I can only hope their offices, with all hands, end up in another dimension. With evil bees.
I'll believe this lives up to the series the moment I see the credits roll after blowing up the final boss. It won't, in many ways, but if it can keep me engaged and entertained not only the first time through but the sixth, like Fallout/2, I'm sold. Fallout 2 still holds my record for longest single gaming session (84 hours, set long, long ago), and if they top that, I'll tattoo their name on myself.
And, should worse really come to worse, we've always got the community to balm our collective wounds with their tweaks, mods, and TCs.