1) Adventure
2) Space sims

Those genres are basically dead. That has nothing to do with consoles, but rather the industry deciding that the genres are either not-profitable (adventure) or done to death (space sims).

The other examples, particularly Mech sims, are quite valid though.

What everyone's ignoring here, however, is the economics. PC games cost vastly more to produce -- not only do you have more coding time (due to the open endedness of the platform and QA work), but you have PC gamers demanding both better graphics (and for as much as people claim they don't matter, I call bullshit -- whenever a game releases screenshots that aren't up to current or next gen standards they get raked across the coals here) and more gameplay. All for less money per game in a smaller market.

I'm all for PC gaming, but I'm also unsurprised that it's becoming increasingly marginalized. I don't think that GFW is going to really solve this; if MS really wants to help, they should do their utmost to improve the APIs and beat hardware makers into releasing quality drivers. Neither of which they're really doing (they are forcing better drivers in Vista... but only for 64-bit. That's not going to help most users).