You know motherboards or something have a limited number of bootups before they stop working
Actually, that's very true for hard drives. The motors will give out after spinning up a few ten thousand times (for desktop drives; laptop drives are designed for several hundred thousand). Typical numbers are 15-30k for desktop drives and 100-300k for laptop drives.
And if you doubt me, then just set your drive to go to sleep after 1-2 mins of inactivity and then setup something to hit it every 3-4 minutes. Your drive will die inside a few months, as people have discovered the hard way.
Of course, leaving your drive on non-stop for 24/7 will kill it too, especially if you don't have enough cooling.