Yes, there are some fundamental assumptions you have to make, but they are not based on blind Faith
there really isn't much difference between 'assumption' and 'faith' if you think about it.
if you're trying to tell someone to solve a problem and you tell them to assume X=3. What if that person asks you, "why is X=3, what do you tell them? you have to just take it on faith that X *IS* 3 you don't prove that X=3, it's just given to you. Faith is also just given to you

you don't explain it, it just is. making assumptions is the same thing.
Another way to look at is this. Many people, including myself, believe that there must be intelligent life elswhere beyond our solar system. Prove it. you can't. We take it on faith that there must be something else out there besides us. Sure you could prove that given the probable size of the universe, that its statistically impossible for there to not be other life out there, but statistics is still just a guess...still faith.
I'm not saying one is right and the other is not. I just see the fanatics dancing around each other, fighting over who is right and I just have to ask, what does it accomplish? does it stop you from believing in science if the religious fanatics win...does it stop you from having faith if the scientific fanatics win? dont you think its awfully petty for these people to argue with each other and try and convince each other that they are right and the other is wrong when in the end, its still up to *you* to decide. fuck what the 'scholars' think.
and at the end of the day, does it make a difference? does knowing the meaning of life change the fact that you still have to go to work or school? does it help you do your taxes? I choose to believe there is room for *both* science and spirituality in my life. to eliminate one or the other seems stupid.