X2 Wolverine's Revenge takes fans back to the Weapon X facility in 1968 when Wolverine's horrific skeletal adamantium bonding experiment had been performed. Players then fast forward to the present and find Wolverine in fellow X-Men comrade Beast's™ lab undergoing tests, when Beast and Professor X™ tell Wolverine that a viral time bomb has been activated in his body and he has only 48 hours to find an antidote by returning to the one place it all began - the Weapon X facility.

In his quest to save his life, Wolverine has the added challenge of encountering familiar foes such as Lady Deathstrike, Sabretooth™, Wendigo™, Juggernaut™ and Magneto. Armed only with his signature adamantium claws, superior senses, advanced stealth techniques and a variety of martial arts moves, Wolverine also enlists the aid of allies such as Colossus™ and Rogue™ as he travels across the Canadian wilderness and finds himself in and out of danger in various Department H facilities and boss battles. X2 Wolverine's Revenge also features the voices of Patrick Stewart as Professor X and Mark Hamill as Wolverine.