So... I tried the game again.
Reminder: First playthrough I ran into SEVEN game breaking bugs until I finished the campaign.
I was pretty optimistic, game now being patch 1.6, PC being freshly formatted, drivers up to date, every other game playing perfectly and a fresh GOG install without earlier saves or config files. Chose Corpo-Rat this time instead of Nomad, just to mix it up. I was ready for 20-30 hours of fun.
How naïve I was...
1 hour and a bit in I had already encountered 3 pretty strange bugs then a CTD as a cherry on top.
Bug 1: When coming back from the scavengers rescue mission, was stuck in the parking lot elevator. The "hand" that is supposed to pop up to activate the elevator touch screen never showed up. Save, reload, "fixed".
Bug 2: Got to V's apartment, was about to go in but... No contextual pop-ups to open the door? Back away, go back to it, nope... Save, reload, "fixed".
PC had been running all day, chose to restart it just in case. Start the game again after reboot...
Bug 3: So I get in, put V to bed, wake up, I was about to head out but decided to check the menus. I click "crafting" and welp, FPS drops like a rock for like 5-6 seconds. What the heck? Then I click an item to try crafting and... yeah, you guessed it, CTD and "Oops, CP2077 has flatlined" error message.
HAHAHAHAHA, needless to say, the game has went right back to uninstall oblivion.
Gonna try again in a year... I guess?