Starting and stopping
When your game starts, Denuvo Anti-Cheat starts automatically.
When your game stops for any reason, Anti-Cheat stops automatically.
Although Anti-Cheat starts with the game, actual monitoring only happens during multiplayer matches.
From Bethesda's site. I would like proof any monitoring only starts during multiplayer, despite starting up when the game launches.
I have only touched single-player, so far. Was looking forward to the single player dlc's coming, but not so much if Denuvo is required now.