I read the article on the pill that may help with loneliness. I really hope that they make some strides with it.
I'm at an age and location where there are extremely few singles (the fewest in the US of any mid-sized or larger city) that's extremely religious, and I just can't work through the mental gymnastics that being religious requires (though I sure have tried... Maybe Religion is another "fake it till you make it" thing?)
I'm literally shot down every time I ask anyone to hang out, can't even tell you the last time I met someone I'd be interested in (and it's rare to find anyone who's even single +/- 10 years of my age; The singles meetups are filled with the elderly, and the local college is, well, a college) People from work don't want to hang out. I had a small group of friends who I watched anime with occasionally that has all but fallen apart, and I'm going to a number of meetup groups, but no real connections there, and most of them are an hour each way (since most are in a neighboring larger city).
I want to move, but most jobs in my field (programming) are also in places that are ungodly expensive (though thankfully... less godly in the literal sense, in that not 90% people are in the predominant religion)
If I could just count on eating a freaking meal with another human being a couple of times a month, I'd probably feel a lot better.
Though energy is another factor. I've got some bad fatigue issues, and have to lie down for much of the time not spent working. It really makes the hour-each-way to meetup groups after work seem daunting.