I like space opera, and I like Mass Effect, Andromeda very much included (it would be a game worth some serious bragging if the dialog animations were good, and all the characters as well-done as PeeBee (is she the Sally Struthers looking chick from The 100, btw?). But I'd love to see something more toward my preferred part of the spectrum, too. Fuel is a finite resource with real costs, so you never send the ship down to the planet. You park it way out near the edge of the gravity well, and you send a pod in. And it's going to be expensive as Hell to get a pod back out, so you better be making some money by sending it down, or have some other really good reason. Most people travel between planets when they are making a permanent move, not for leisure, unless they're rich. Places with serious gravity wells aside, even so the cost of interplanetary travel is substantial, so you need good reason to move. Profit, or something similarly motivating (and the only stuff worth trading is stuff they can't make down on the planet, and stuff you can't get closer to home). You don't do a lot of maneuvering if you can help it. AIs probably control most aspects of flight. There's a lot more movement between space habitats, where the costs usually don't involve breaking free of those pesky gravity wells. Interstellar travel is almost exclusively a generation ship/permanent colonization thing. Time dilation's real, so you can't just cross the galaxy and come back for dinner at mom's.
I think there's a lot of room, even with the myriad constraints, for some pretty crazy epic sci-fi in there. And if you weave the realism into the game the right way, you can get a lot of immersion points. And there are lots of ways to force hard choices on the player with those constraints.
Globalization's all the rage right now, but all the facts point to a globe being the limit of globalization's potential. Maybe a star system. Other star systems are just too far away to be governed by the same authority, or part of the same integrated system.