Out of the Blue

Happy National Fruitcake Day! I actually tend to like fruitcake, but I haven't had any in a really long time, so I may not feel that way if I had some right now. Holiday foods aside, we had a rare visit to the movies on Christmas, as we went to see Rogue One. I can see why the reviews on this are mixed, as I have mixed feelings about it myself. There were parts I loved, and parts I didn't, but on balance the experience was positive, and I was happy to have seen it, and happy to have made the effort to do so in the theater. But I also just like movies in general, so in the same way I wouldn't be a good video game critic, I wouldn't be a good movie critic. Also, I probably would have considered the movie enjoyable if they just had Alan Tudyk's part surrounded by footage of cows grazing, so you may not want to go by me.

R.I.P.: Everybody Hates Chris Star Ricky Harris Dead: Actor Dies at 54.

Roguish Links: Thanks Ant and Acleacius.
Play: Anti Chess.
Story: CHP Officers Stunned by Use of Zip Ties in Place of Car Chains.
Science: USDA Develops Rapid Test for Imported Red Fire Ants.
Disappearing Spots - Panthera.
Media: Captain Picard sings "Let it Snow!"
Fan-O-Rama: A Futurama Fan Film. Thanks HARDOCP.
Peacock Spider Christmas.
Follow-ups: George Michael's philanthropy comes to light after his death.
George Michael's boyfriend reveals he died alone at home and 'battled a secret heroin addiction.'
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53.
 
Re: Out of the Blue
Dec 28, 2016, 18:02
Kxmode
 
53.
Re: Out of the Blue Dec 28, 2016, 18:02
Dec 28, 2016, 18:02
 Kxmode
 
jdreyer wrote on Dec 28, 2016, 13:17:
Big Pharma is not altruistic in the least. There are generics because the government sets the patent expiration for drugs at 20 years. Don't fool yourself: the drug companies salivate at Disney's 90 and 120 copyright expirations. And they develop slight modifications of existing drugs, market them and get approval as new drugs, and then sell them at the protected price even though they're not any better than existing drugs. And don't even get me started on Skreli or Epipen.

Fortunately they are one of the more heavily regulated industries, so the damaging aspects of capitalism are mitigated and they're able to provide an overall good. Could see that change under Trump, who wants to deregulate a lot of stuff. Wait until "market forces" come into play because of 100s of people dying from a bad drug.

Authorized generics are authorized by the pharmaceutical typically after their 180-day (3-year) exclusivity period. This is to allow them to recoup their costs for R&D and approval. This is precisely why in 2012 that aforementioned $180 30/day supply was now available to me in 30/day generic form for $10. In other words, I didn't have to wait 20 years for a generic to become available.

Regardless of regulation and Wall Street, the process of bringing a drug to market is strict. For example, pharmaceuticals need to file an Abbreviated New Drug Application (ANDA) with the FDA that seeks to demonstrate therapeutic equivalence to a previously approved "reference-listed drug." They must prove they can manufacture the drug safely and consistently. For an ANDA application to be approved, the FDA requires the bioequivalence of a generic drug to be between 80% and 125% of the innovator product. Additionally, the FDA adds the generic drug to its Approved Drug Products with Therapeutic Equivalence Evaluations list (ADPTEE) and annotates the list to show equivalence between the reference-listed drug and the generic. There are also laws and regulations that generic pharmaceutical companies must follow but the overall scope of these regulations is to protect the public. (Information gleaned from Wikipedia with references.)

That being said are their issues with gross misconduct? Absolutely. But this is the exception instead of the rule. For the most part, the FDA helps make medicine less expensive for all.
"Hard times create strong men. Strong men create good times. Good times create weak men. And, weak men create hard times." - Those Who Remain by G. Michael Hopf
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