I actually like some of the changes, like the removal of skills. I never really got much out of adding a few points to a skill, which may or may not cross some threshold to make it more useful. Rolling those into the perks seems like a better way of doing it to me.
I expect problems and patches early on, but I still plan to play it and have fun with it, because that's always how it goes with Beth's games. They transcend their flaws.
"The whole problem with the world is that fools and fanatics are always so certain of themselves, but wiser people so full of doubts." -- Bertrand Russell (I think...)