Sadly the PC version won't get much special treatment, he admitted: "We're definitely supporting PC, we love PC, but I think it'll be PC with a controller. I don't see us investing hugely in a mouse and keyboard setup. I think if you want to play on PC and you want to play Assassin's Creed, you have a controller."
A real argument could be made that the "best" way to play is the way the developers designed the game to be played, which is with a pad.