I also had some trouble with cities (not catastrophic but lower frame rates) and the best thing I found to improve things is in SkyrimPrefs.ini:
Check your value isn't higher than this, mine was 8000 although that may have been from a shadow mod's ini file while I was experimenting. It's the distance at which shadows are drawn, setting at 3000 is almost never noticable in towns and saved me a great deal of FPS, even with the quality of shadows set highter than Ultra. In the open wilderness 3000 is a little noticable though, we'll need a util to set these kinds of values depending on interior, exterior and wilderness locations I think. Also I suspect the FPS loss in cities is caused by CPU limit not GPU limit in many cases, mine was.
Edit: oh and I didn't really notice a performance increase with these drivers but I have not had a single crash since. Before while using one of the FXAA injectors I was CTDing occasionally.