Having a GREAT time with this game so far.
Not only that, I'm playing it on my old, E8400, GTX280(with updated drivers of course), 4GB RAM. The game picked high settings and I haven't bothered tweaking that yet as it looks great. I imagine further driver updates will improve it more.
I was really getting worried about having to upgrade before the 7xxx series cards got here early next year but now I'm just going to wait until the 7xxx/6xx wars figure themselves out and upgrade then. The only other game I'm even going to try is SWTOR and my good 'ole gtx280 will hold up just fine.
My one gripe with Skyrim so far... ya, the UI. It's not like it's totally broken, but developers really, REALLY need to just accept the fact that mouse/keyboard and console controllers are far too different to attempt to combine. If the mod community can do it relatively quickly , why can't the developer? I think they must get blinded by the console controller UI having to work so much with it and truly think the PC UI seems natural and good. It isn't.