Yeah, in solo. I can only get to the second mission before it will give a system hang, requiring a cold restart of the PC. Despite the complaints people have about Vista, this is the first thing I have seen in 14month of using Vista 64 that can completely hang the system.
Take a trip over to Relics support forum, and you will see people complaining of not your run of the mill bugs (features not work, slow graphic performance) but of system hang bugs. The number of posts is stunning - there were over 50+ new threads of such bugs just in the past 24 hours.
It seems some people have no issues, and others nothing but. There is a couple of threads of what to do when you hit system freeze bug 'A' (disable all audio, replay mission) then people are good for a couple of missions until they hit system freeze bug 'B'. And so on.