I preferred the Gothic 1 control scheme:
arrow keys (run/look/use - right hand), left ctrl (action -left pinky), spacebar (draw/put away weapon - left thumb), z (strafe left - left middle finger), x (strafe right - left index finger). That's it. Never ever had to screw with the mouse. It was a very comfortable control scheme, IMO.
On the other hand, if you want to use the mouse look and wasd, you can map the keys.
I still can't get over the fact that some serious pc gamers missed out on this game. What a shame.