The show is decent. I rarely like a show in its first season as the actors have not grown into their characters and the producers haven't settled on a direction, but I've been enjoying Defiance so far. It also gets boosted by the fact that you have very few other choices on TV for sci-fi anymore. Take it where you can get it.
I haven't played the game. Seems like Third person shooter + GW2 + Rift from the videos I've seen from Total Biscuit and others. It's good to see a slightly more inventive mix of elements in an MMO instead of hotbar gear grind shitfest, even if it isn't amazing.