The Wire isn't like the CSI/NCIS crap. I've never been a fan of any cop drama show before but I'm a huge fan of The Wire. Started watching it back in July and I'm now two episodes into the final season (5).
It's as much about the "bad guys" as it is the good, and at times I've got to remind myself it's fiction and not a documentary. Very well written and acted but most HBO stuff is.