I couldn't play Skyrim without mods, there are so many good ones. I'm in the process of converting my Nexus crap over to Mod Organizer. It lets you install mods as a virtual container which is amazing. Mods are never really "installed", MO basically gives them to Skyrim at runtime so you never run into a situation where a mod screws up an install. You could try 1000 different mods and be back to vanilla with a single click. You can also have different save profiles and you can have different mod profiles for each character. Amazing utility but there is a bit of a learning curve.
Oh yeah and uh, Origin and stuff.
Playing: XCOM 2, Diablo 3 Watching: American Crime, Regression