I prefer to play these sorts of games with a 360 controller. I don't own a console. If the game is being made for both the 360 and the PC, the resources needed to make sure I can use the controller on the PC are tiny.
Not being able to use my controllers means I'm not picking up this or Mass Effect2. I'm sure they're awesome, but at least I've got other good games to keep me busy that have controller support. I may come back to pick these up at some point down the road, but they won't be first on the list.