Eh, I'm not even sure what a true PC game is. The consoles are just poor man's PCs with shitty controls (for some genres) that results in horrible game castration in some cases.
We need to lose stuff like aggressive auto-heal, auto-crouch/cover, and auto-aim. Include configurable non-stupid key mappings. UI text that's not 40pt font size across the board. 4:3, 16:10 and 16:9 screen ratios that work properly. An at-my-will saving system (although this isn't a real issue for me honestly).
This post almost exactly describes my feelings after purchase of Red Faction Guerrilla, Borderlands and then Mass Effect. At least I got Mass Effect for only $10.