I've been running 64bit Vista on my desktop and my gaming laptop for about a year now and I can easily say that I'll never go back to XP. I've had zero issues with either computer, and all games have run amazingly well.
Anyhow, I think it's silly for people to keep complaining about XP starting to lose support for certain things. They can't support it forever. They've got to force a change eventually. It's similar to the HD signal switch over for TV's. People have known about it for at least a year because they've been spamming the commercials on the over the air channels, yet some people still haven't purchased convertors and they will act surprised... they just need to switch and get it over with.