Jennerstein, I'm left-handed and know exactly what you are talking about. These days the first time I load a new game, I'm almost waiting for the menus to come up to see if my primary button is going to work properly.
Game devs, ARE YOU READING THIS?
And to the guy who mentioned a standard for this stuff, that is a wonderful idea. I don't think some people here quite understood. How cool would it be to start a new game and have the ability to import key bindings from an external file? BOOM! Done.